Knowledge catalogue
A couple of months ago, I announced that I was partway through implementing a simple, readable AlphaFold2 in pure PyTorch, inspired by @karpathy's minGPT. Today, I'm happy to share minAlphaFold2 - the
AI ASCENT IV 4/20/2026 Our best event yet. This year's theme: AI AT THE FRONTIER. Robots. Data centers in space. New chips. BCI. Hosted by @Konstantine @gradypb @Alfred_Lin and all of us at @sequoia 💚
arXiv:2604.18955v1 Announce Type: cross Abstract: In this study, we present the first comprehensive evaluation of modern LLMs - including GPT-4, GPT-4o, GPT-3.5-Turbo, Gemini 1.5 Pro, DeepSeek-V3, Lla
We are officially moving past the era of one-size-fits-all AI. Enterprises today require highly specialized, role-specific tools to drive real productivity — but they cannot afford to sacrifice securi
@Konstantine @gradypb @Alfred_Lin @sequoia @demishassabis @karpathy @gdb @bcherny @djseo @zoink @matiii @DrJimFan @oegerikus @amspector100 @bfspector @PhilipJohnston @NaveenGRao @annadgoldie @Azaliami
arXiv:2604.19117v1 Announce Type: new Abstract: When a language model agrees with a user's false belief, is it failing to detect the error, or noticing and agreeing anyway? We show the latter. Across
NVIDIA and Google Cloud have collaborated for more than a decade, co‑engineering a full‑stack AI platform that spans every technology layer — from performance‑optimized libraries and frameworks to ent
Read THIS by @huggingface’s @ClementDelangue, @YJernite and @mmitchell_ai “Openness provides defenders with the visibility, the control, the community, and the shared infrastructure to stay ahead.” ht
arXiv:2604.05301v2 Announce Type: replace Abstract: Real-world smoke simultaneously attenuates scene radiance, adds airlight, and destabilizes multi-view appearance consistency, making robust 3D recon
Treehub, a new Stanford University-adjacent residency program backed by the AI Health Fund, launched today, with billionaire investor Tim Draper and 23andMe Holding Co. founder Anne Wojcicki among the
AI is evolving from answering questions to reasoning and taking action. Companies who want to lead in today’s agentic era require computing infrastructure designed and optimized for these new requirem
arXiv:2511.16857v3 Announce Type: replace Abstract: Vision Language Models (VLMs) have achieved impressive performance on spatial reasoning benchmarks, yet these evaluations mask critical weaknesses i
gpt image 2 can do some reallly hard prompts well I present - the periodic table of Pokémon ok so... gpt image 2 did this pretty well not everything here is perfect and a lot of the images are off but
Hi i'm dwarkesh! Grew up all over the US, now sf-based and always down to nerd out about AI, science & history :) a lil about me: 🟠 Host of the dwarkesh podcast 🟠 Studied at UT Austin 🟠 Just published
I was kicked off the AI Ascent swag committee bc of last year’s “ai a scent” candle nonsense 😂 This year @Alfred_Lin leveled us up. Can’t wait for the aliens to find our AI Ascent 2026 swag one day. “
If you are inclined to take @ohabryka on his word on issues like this, you may want to know some context... Oliver accuses me and ControlAI of telling people to be more coy about extinction risks. I h
it's entirely fine and great for proprietary models to exist the issue is they try to kill open source behind scenes while pretending they support it so far they've been pretty incompetent but they'll
It’s time to go beyond language models. Introducing Odyssey-2 Max, our most powerful world model yet. It materially advances the SOTA in physical accuracy. This is a big step toward models that simula
Share this with your representative! https://huggingface.co/blog/cybersecurity-openness I’m hearing there’s renewed lobbying in DC and in state legislatures to ban or severely restrict open-source. Li
How does the physical matter in our brains translate into thoughts, sensations, and emotions? It’s hard to explore that question without neurosurgery. But in a recent paper, MIT philosopher Matthias M
Sonya Huang spoke at Sequoia's AI Ascend event about Starcloud alongside notable AI figures including Andrej Karpathy, Greg Brockman, Demis Hassabis, and others, highlighting significant perspectives
This post from AI researcher Yohei Nakajima is a motivational message wishing readers a successful week, combined with a brief security reminder to rotate secrets (likely referring to API keys, passwo
Kimi K2.6 just dropped. And it crushed Claude Opus 4.6 on SWE-Bench Pro. Kimi K2.6: 58.6 GPT-5.4 xhigh: 57.7 Gemini 3.1 Pro: 54.2 Claude Opus 4.6: 53.4 An open source Chinese model is now #1 on agenti
The Korea Herald: SK hynix says it has begun mass production of the 192GB SOCAMM2, a next-gen LPDDR5X low-power DRAM module designed particularly for Nvidia's Vera Rubin — SK hynix Inc. said Monday it
Abram Brown / The Information: A look at Dylan Patel's SemiAnalysis, an AI newsletter and research firm that expects $100M+ in 2026 revenue from subscriptions and AI supply chain research — For Dylan
And there are many really good AI components at Google: they have top-flight image, music, & video generation, and good UIs for each of them. Google AI studio is probably the best playground for AI ex
Qianer Liu / The Information: Sources: Google is in talks with Marvell Technology to develop a memory processing unit that works alongside TPUs, and a new TPU for running AI models — Google is in talk
1/ Old Nvidia chips are getting MORE valuable with age, not less. That has never happened in computing history. Marc Andreessen (@pmarca) on @latentspacepod with Alessio Fanelli (@FanaHOVA) and @swyx
30K+ likes in the first hour. 🤯 That is crazy! Design is unsolved with agents. But lots of impactful work generated by agents is around design. Claude Design is Anthropic's way of saying that they are
Zvi Mowshowitz / Don't Worry About the Vase: A deep dive into Dwarkesh Patel's interview with Jensen Huang, including Huang's takes on Nvidia's moat and chip sales to China, and reactions to the inter
Data Driven Agent Design with Evals & Hill Climbing Algorithms this is a mental model dump i’ve been thinking through + iterating on as we’re building self-improvement infra around agents: - mining Tr
arXiv:2604.15027v1 Announce Type: new Abstract: Significant progress has been made in detecting synthetic images, however most existing approaches operate on a single image instance and overlook a key
Financial Times: Sources suggest Anthropic is holding off from a wider Mythos release until it can reliably serve it to customers; Anthropic has suffered outages in recent weeks — Dario Amodei met wit
“The sharpest drop came from people who used the model for direct answers, not from those who used it more like a hint system, which suggests the real issue is not AI exposure itself but replacing eff
To go deeper on our new Life Sciences model series, research lead @joyjiao12 and product lead Yunyun Wang joined @AndrewMayne on the OpenAI Podcast to discuss how we’re building models for biology, dr
Emad Mostaque, founder of Stability AI, posted a birthday message on his 43rd birthday reflecting humorously on not discovering the meaning of life at 42 (a reference to Douglas Adams' 'Hitchhiker's G
What folk don’t get is that the play of Anthropic et al is to get enterprises to use their models via their own wrapper hooked into systems of record This is why they are moving from per seat pricing
a company called @simple_closure that helps startups wind down is launching 'asset hub', which is a marketplace to sell all the old slack/email data apparently they are working on hardening the PII re
Completely agree with Jensen! Not exporting AI out of fear is classic case where the cure would be 100x worse than the disease. You slow down innovation, progress and US technology and economic leader
@GaryMarcus Essentially your prediction that LLMs to scale wouldn’t solve key fundamental problems, reasoning, factual reliability, compositionality, grounded understanding etc are now elephantine chi
For anyone who has been (inadvisably) taking my pelican riding a bicycle benchmark seriously as a robust way to test models, here are pelicans from this morning's two big model releases - Qwen3.6-35B-
The Information: Sources: OpenAI agrees to pay Cerebras $20B+ to use its server chips, double the amount previously associated with the deal, and may receive equity in Cerebras — OpenAI recently struc
Dylan Patel of SemiAnalysis posted a clarification on X distinguishing NVIDIA from automotive companies, likely in response to comparisons or confusion surrounding NVIDIA's growing presence in the aut
We replicated Mythos findings in opencode using public models, not Anthropic's private stack. The moat is moving from model access to validation: finding vulnerability signal is getting cheaper; turni
While I am not involved in the Bittensor ecosystem I would recommend that they try a council of LLMs style of governance support for all proposals they propose. These should be checked against the whi
arXiv:2511.17537v2 Announce Type: replace-cross Abstract: Wireless Sensor Networks (WSN) are the backbone of essential monitoring applications, but their deployment in unfavourable conditions increase
I find it fascinating that OpenAI's Global Affairs team will denounce AI doomers for being too negative and then, simultaneously, advocate for an Illinois bill that would shield them from liability if
arXiv:2604.12034v1 Announce Type: new Abstract: Retrieval-Augmented Generation remains the dominant pattern for giving LLMs persistent memory, but a visible cluster of personal wiki-style memory archi
proud to see @excalidraw evangelism catching on at cog the insight here is more general than bugchecking: - All Engineering is about making tradeoffs - AI Engineering is about pushing AI Pareto Fronti
Norwegian defense technology startup Stendr said today it has closed on 5.4 million in pre-seed funding in order to deliver advanced artificial intelligence capabilities for modern weapons systems. Th
🆕 The Full Story of Notion AI https://latent.space/p/notion We're so excited to chat with @simonlast and @sarahmsachs about Notion's 'Token Town' - the crack team of AI Engineers and Model Behavior En
arXiv:2604.11272v1 Announce Type: cross Abstract: Accurate prediction of antibody-antigen binding affinity is fundamental to therapeutic design, yet remains constrained by severe label sparsity and th
Quantum computing is moving from hype toward practical integration with high-performance computing and AI systems, driving greater quantum HPC integration. Throughout history, each wave of technologic
arXiv:2604.11154v1 Announce Type: new Abstract: New multi-modal large language models (MLLMs) are continuously being trained and deployed, following rapid development cycles. This generative AI frenzy
arXiv:2604.02600v2 Announce Type: replace-cross Abstract: Developing a novel research idea is hard. It must be distinct enough from prior work to claim a contribution while also building on it. This r
This r/StableDiffusion thread seeks community recommendations on AI image generation tools, reflecting a common discussion in the subreddit where users compare options like Stable Diffusion (run local
Alyssa Lukpat / Wall Street Journal: Maine's legislature passed a bill blocking new data centers that exceed 20 MW capacity until November 2027, making it the first state to enact such a measure — The
Artificial intelligence powerhouse OpenAI Group PBC is lending its expertise to Novo Nordisk A/S in a new partnership announced today that aims to accelerate research in the pharmaceutical industry. T
arXiv:2602.00793v2 Announce Type: replace-cross Abstract: Speaking aloud to a wearable AR assistant in public can be socially awkward, and re-articulating the same requests every day creates unnecessa
arXiv:2604.09649v1 Announce Type: cross Abstract: Brain-computer interfaces (BCIs) have opened new platforms for human-computer interaction, medical diagnostics, and neurorehabilitation. Wearable BCI