Research
Enhancing In-Hospital Mortality Prediction Using Multi-Representational Learning with LLM-Generated Expert Summaries
arXiv:2411.16818v2 Announce Type: replace-cross Abstract: To evaluate a multi-representational framework in which large language model (LLM)-generated expert summaries of intensive care unit (ICU) not
arXiv:2411.16818v2 Announce Type: replace-cross Abstract: To evaluate a multi-representational framework in which large language model (LLM)-generated expert summaries of intensive care unit (ICU) notes are fused with physiology for in-hospital mortality (IHM) prediction, and to determine how much of the resulting gain is non-redundant with the notes themselves. Using MIMIC-III (19,211 first ICU stays, 12.83% mortality), we encoded 48-hour physiology, clinical notes, and LLM summaries generated under a prompt forbidding prognostication, then fused them. Redundancy was assessed by ridge recoverability, linear probes, and retrained ablations substituting a note-orthogonal residual or a patient-shuffled summary embedding. On 3,843 held-out stays, fusion reached AUPRC 0.4977/AUROC 0.8429 versus 0.3625/0.7770 for physiology alone. Ridge regression from note embeddings explained 40.8% of summary-embedding variance. The note-orthogonal residual retained a minority of the gain (+0.0258 AUPRC, 95% CI 0.005--0.047; 28%), while patient-shuffled summaries fell below the reference. Summaries improve prediction patient-specifically, but predominantly by reorganizing information the notes already contain.
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Source: arXiv cs.AI | 2026-08-14