Research
ESMFold2 is a state of the art folding model. It's crazy good. The -Fast model does better on antibody-antigen complexes than AF3 with MSAs.
ESMFold2 is described as a high-performance protein structure prediction model that demonstrates particular strength in predicting antibody-antigen complex structures, reportedly outperforming AlphaFo
ESMFold2 is described as a high-performance protein structure prediction model that demonstrates particular strength in predicting antibody-antigen complex structures, reportedly outperforming AlphaFold3 with multiple sequence alignments according to its evaluation on the Fast variant.
Source: Yann LeCun (X) | 2026-05-27