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🔬ESMFold2: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
ESMFold2 represents an advancement in protein structure prediction leveraging scaling laws and transformer-based language models, building on principles that favor compute and data scale over hand-cra
ESMFold2 represents an advancement in protein structure prediction leveraging scaling laws and transformer-based language models, building on principles that favor compute and data scale over hand-crafted features. The presentation discusses how large-scale machine learning approaches are increasingly outperforming traditional domain-specific methods in protein folding, reflecting the "bitter lesson" that general-purpose learning systems often exceed specialized approaches as computational resources increase.
Source: Latent Space | 2026-05-27