today was a massive day for protein engineering. esmfold2 dropped—next gen of the esm series, fully open on @huggingscience. 1.1 billion pre…

today was a massive day for protein engineering. esmfold2 dropped—next gen of the esm series, fully open on @huggingscience. 1.1 billion predicted structures, 6.8 billion sequences. 800m more entries than the alphafold db, and reportedly edging out alphafold3 on protein complexes, including antibody–antigen binding. alongside it: the new esm atlas. a huge expansion of known protein space, heavy on metagenomic sequences from soil, ocean, and the parts of biology that have been least characterised (until now!!) and if that weren't enough, litefold dropped the fineweb of proteins, so every major protein database (pdb included) aggregated, cleaned, and made plug-and-play in one place. these are the releases that push the whole field forward, and the pace of open science right now is almost motion-sickness inducing all of it on http://huggingscience.co (and ofc @huggingface)

Source: Yann LeCun (X) | 2026-05-27