Knowledge catalogue
Trump’s “little excursion to Iran” is 'universally perceived as a defeat. Almost regardless of the outcome – most likely a return to the…status quo – the war looks ill-conceived, a monument to confuse
卧槽！你随便扔一首 YouTube 歌，它就能直接拆成 6 条独立音轨——人声、鼓、贝斯、吉他、钢琴、其他……全给你扒出来！ 这工具叫 StemDeck，GitHub 开源项目，本地跑全程不上传、不注册、不花钱！它基于 Demucs 模型，拆完后给你一个接近 DAW 的界面： 静音、独奏、拉推子、缩波形、设循环、单轨下载、混音导出……想怎么玩就怎么玩。硬核亮点： 本地全速运行：自动识别 GPU，A
Bill Gurley: Anthropic Thinks It’s Building God @Jason: It is the ultimate level of narcissism and delusion of grandeur to think you can create God. @bgurley: “Anthropic is a mystery to me. I've never
Exxon Says We’re Two Weeks From Petrol Armageddon Right. So it turns out closing the world’s most important oil chokepoint has consequences. Who knew. Exxon’s Senior VP Neil Chapman stood up at a Bern
I'm MAGA's twisted sense of reality and morality, a scientist who developed treatments and vaccines that have saved hundreds of thousands of lives (without getting rich from it) should be sent to Gitm
In my Harvard fellowship I study the views of AI accelerationists, safetyists and skeptics. What I have come to realize is that both the Accelerationists and the Safetyists believe that we are creatin
Took me a while to figure out what all the ESMFold2 rage was about. At first, the benchmarking data didn't look super remarkable to me but it turns there are many impressive aspects: - Fully open sour
Woah. A profound shift in American science is coming. Every federal research grant could soon require sign-off from a political appointee. Scientific progress depends on funding decisions grounded in
Yann LeCun, a pioneering AI researcher, provides his definition of what constitutes a world model in this X post. A world model is an AI system's internal representation of how the physical world work
Economy then vs now: GDP growth: 2024 2.8% 2026 1.6% Inflation: 2024 2.9% 2026 3.8% Wages: 2024 rising faster than inflation 2026 rising slower than inflation Unemployment rate: 2024 4% 2026 4.3% Jobs
Elon Musk: If Kamala wins she'll hide the Epstein files, & be a threat to democracy. If Trump wins he'll release the Epstein files, & focus on the people. This idiot has NEVER been right about anythin
NEW: Aleph Prover has formalized OpenAI’s disproof of Paul Erdős’ planar unit problem. We are releasing the formalization as open source so that other researchers can inspect, extend, and independentl
Our team at @AIatMeta is excited to announce ATLAS: one of the largest automated formalization efforts to date. ATLAS contains Lean 4 formalizations of both statements and proofs from 25+ mathematics
This week alone: DOJ opens an investigation into the woman Trump raped. The White House is caught steering a 620 million contract to Don Jr.’s firm. The Pentagon hands out a 10 billion contract after
Would you like to join the research effort on JEPA and World Models easily? After a full year of hard work, we’re excited to finally release stable-worldmodel: an open-source, scalable platform built
Yann LeCun discusses his perspectives on large language models (LLMs) and reinforcement learning (RL) as approaches for developing world models, presenting arguments he frequently advocates for in the
A closer look at what we released today 🧵 ESMC is a language model trained on billions of protein sequences spanning the full diversity of life. Trained across 2.8 billion sequences, the model is expo
DeepMind's AlphaFold3 and related tools have generated a comprehensive atlas containing over one billion predicted protein structures and additional billions of protein sequences, representing a major
Alex Rives discusses advanced AI models for protein biology on the Latent Space podcast, including ESMFold2 (an improved protein structure prediction tool), ESMC (a protein language model), and ESM At
Announcing ESMFold2, our new state-of-the-art structure prediction model capable of predicting structure from single sequences or MSAs. ESMFold2 improves on benchmarks of protein-protein interaction a
BREAKING: Trump just got busted STEALING all the donation money from his “Board of Peace” fund to rebuild Gaza! This one REALLY takes the cake... When Donald Trump announced he would be creating a new
ESMFold2 is described as a high-performance protein structure prediction model that demonstrates particular strength in predicting antibody-antigen complex structures, reportedly outperforming AlphaFo
First of all, all of this is open sourced. Even the binder design protocol [coming soon], which has been rigorously experimentally validated. Paper: https://biohub.ai/papers/esm_protein.pdf 🤗: https:/
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Get a state of the art protein structure prediction in just 9 lines of code. No MSAs needed. I'm so excited to show the world what we've been working on the for the past months!! I'm going to highligh
Identifiability is what it means to learn the right latent space, the Gaussian is why LeJEPA works, and it's what makes planning transfer. I think identifiability is the right definition of what it me
It is refreshing to have some new arguments pointing at specific distributions (Gaussian) our embeddings must follow! Especially now that we know how to do scalable distribution matching in high dimen
Petraeus: Putin is the personification of evil. He wants to reassemble as much of the former Soviet Union or Russian Empire as he can, and he does not believe Ukraine has a right to exist as an indepe
Proteins are the machinery of life. Scientists have cataloged billions of protein sequences—but their biology is still mostly unknown. Today we're releasing a world model of protein biology: a scienti
This Ebola outbreak has been a slow motion disaster - 900 cases and and now threatening the U.S.. We know how to stop outbreaks like this. But Trump chose not to stop it. He destroyed our global healt
today was a massive day for protein engineering. esmfold2 dropped—next gen of the esm series, fully open on @huggingscience. 1.1 billion predicted structures, 6.8 billion sequences. 800m more entries
Today we're announcing ESMFold2, an open scientific engine to power prediction, design, and discovery across protein biology. The new model delivers state of the art performance on protein interaction
Trump could have presided over a very strong economy. All he had to do was...nothing: Inflation was trending downward, the AI boom was raising growth. Instead, he engineered a global trade war and ene
Trump is now 'the most unpopular president since our poll started in 2009. His net approval rating is -24,' due to his war of choice in Iran and his mishandling of the economy. https://trib.al/G1c4KcW
What does JEPA actually learn? We can finally prove it 🌍 So excited to share our theory of identifiable World Models: LeJEPA recovers the latent variables of the world. Plan in the learned World Model
Yes, it was easier to laugh, or cry, at such lunacy in medical and scientific officialdom in banana republics like Russia before Trump appointed RFK Jr (circumcision and vaccines cause autism, mRNA te
A post about Pope Leo XIV's encyclical on AI. Why the Pope is right, but perhaps not right enough. Artificial intelligence is reshaping the world in front of our eyes: how we communicate, how we acces
This post summarizes key financial metrics from SpaceX's hypothetical IPO filing, highlighting concerning metrics including a 700% increase in losses, decelerating revenue growth, and an extremely hig
Musician and human rights activist Peter Gabriel sent a special congratulatory message to Brewster Kahle, founder and digital librarian of the Internet Archive, on being honored as a 2026 Computer His
The road to Hell is paved with closed-source citadels disguised as good intentions. The Pope is right: AI takes on the characteristics of those who build it, finance it, and regulate it. So the questi
The Telegraph: Macron tore up 65 years of doctrine to defend Europe with French nukes, with or without the US. Poland, Germany, the Netherlands, Belgium, Greece, Sweden, Denmark, and now the Czech Rep
📢 Accepted to TMLR, with reproducibility certification 🏅 v2 of our JEPA-WM study (arXiv:2512.24497) is out, with new data-scaling experiments, a Lipschitz analysis of multistep rollout training, and e
Major difference in my mind: - an engineer, given a problem, invents and tries multiple solutions and stops when the solution is good enough. The goal is product innovation and shipping. - a scientist
The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative
🇺🇸🇪🇺 A new study from the US-based New England Journal of Medicine found that Americans die earlier across all income levels compared to their European counterparts. What’s especially notable is that
And just like that, it’s completely VANISHED from the media. A sitting congressman, Ted Lieu, said on the record the Epstein files are being blocked because they show Trump raped and threatened to kil
During his second term, Trump will have cut 2 of the US most powerful innovation and wealth creation engines: 1. skilled legal immigration 2. (non-defense) research budgets We won't see the effect of
Francis Fukuyama on the U.S. as a declining power: American decline is a direct product of Trump's rise since 2016. It is as if Trump had decided to do everything in his power to weaken the United Sta
This post contains criticism of an unspecified individual, likely a political or public figure, accusing them of betrayal toward their supporters, skeptics, and the nation. The statement appears to be
Historically, the US has been the greatest magnet for talent on earth. Whether that continues to be the case is not inevitable. Nearly half of the founders of billion-dollar tech startups are immigran
If Trump kicking the Tech Right in the nuts doesn't put an end to the Tech Right, I don't know what would Feeling robbed of my path to citizenship right now after grinding a PhD and contributing to fo
“If we erase January 6th, it didn’t happen” “If we don’t release certain inflation data, there’s no inflation” “If we don’t measure food insecurity, no one’s hungry” “If we delete research on right-wi
The Journal of the @americanacad just published a new issue of Daedalus on AI and Science, edited by James Manyika. It has terrific line-up of contributors, including @demishassabis, @ylecun, Josh Ten
Why? Most green-card applicants will need to go abroad to apply for permanent residency at an American consulate, rather than filing from within the U.S. as they do now, the Trump administration annou
Closed and gated surveillance economy SaaS systems and models will get replaced by open source in two tiers: - The models themselves - The everything-ultra-app harness If an American open source champ
Eight key points from the most recent essay in the “AI as Normal Technology” series by @sayashk and me. Do AI Risks Require Extraordinary Government Intervention? 1. There is general consensus that AI
Howard Lutnick's FIRST political donation since becoming Commerce Secretary was a $5 MILLION donation to House Republicans 1 month before they interviewed him about his ties to Jeffrey Epstein. Let th
It’s a rough time to be a scientist. You spend decades learning how to measure things properly. How to separate signal from noise. How to distinguish hazard from risk. And then you open your phone and
My new article 'Toward a science of intelligence: unifying physics, neuroscience and AI' https://www.amacad.org/publication/daedalus/toward-science-of-intelligence-unifying-physics-neuroscience-ai pub
Open weight models running on open source harnesses solve this problem. One of these days, American companies will wake up to the same solution we pioneered decades ago that Chinese teams are now runn